Pesticides in the Blood Samples of Spray-workers at Agriculture Environment: The Toxicological Evaluation

  • A.M. Soomro Faculty of Pharmacy, University of Sindh Jamshoro, Pakistan
  • G.M. Seehar Department of Physiology, University of Sindh Jamshoro, Pakistan
  • M.I Bhanger National Center of Excellence in Analytical Chemistry, University of Sindh Jamshoro, Pakistan
  • N.A. Channa Institute of Biochemistry, University of Sindh Jamshoro, Pakistan

Abstract

Pesticides are major contaminating chemicals in agriculture environment and a hazard to exposed population. These compounds are absorbed by inhalation, ingestion, and dermal contact. Their bioavailability in the individuals can lead to a variety of metabolic and systemic dysfunctions, and even outright disease states. Therefore, the tremendous usage of pesticides has promoted toxicological studies in spraying community. This study comprising pesticide spray-workers (n=140) and controls (n=110) indicated highly significant effects by analytical means on serum cholinesterase level (p<0.001) through ANOVA. Duncan Multiple Range Test ranking for monocrotophos and carbaryl were similar though different than endosulfan and cypermethrin, which conceptualized the effects on cholinesterase level. The GC-MS detection of residue concentrations in blood serum samples of spray-workers; calculated for endosulfan, monocrotophos, carbaryl and cypermethrin were 0.009, 0.005, 0.05 and 0.08 mg/kg body weight respectively. It was further seen in light of reported NOAEL that indicated the effect and extent of exposure among the study population. 

Published
Jun 2, 2008
How to Cite
SOOMRO, A.M. et al. Pesticides in the Blood Samples of Spray-workers at Agriculture Environment: The Toxicological Evaluation. Pakistan Journal of Analytical & Environmental Chemistry, [S.l.], v. 9, n. 1, p. 6, june 2008. ISSN 2221-5255. Available at: <http://pjaec.pk/index.php/pjaec/article/view/151>. Date accessed: 23 nov. 2017.