Determination of Pioglitazone Hydrochloride in Tablets by High-Performance Liquid Chromatography

  • horvertech
  • A. L. Saber Department of Chemistry, Faculty of Science, Zagazig University, Zagazig, Egypt

Abstract

A rapid and accurate HPLC method has been developed for the determination of pioglitazone hydrochloride in tablets. Chromatographic analysis was performed on a Nova-Pak fi C18 column (3.9mm x 150mm, 5m) with a mixture of ammonium formate buffer adjusted with formic acid to pH 3 and acetonitrile (75:25, v/v) as mobile phase, at flow rate of 1.0  mL min-1, and UV detection at 225 nm. The determination was completed in less than 12 min. Linearity ≥ 0.5 gmL-1, accuracy ≥ 99.14 %, and precision ≤ 0.6 % were found to be acceptable over the range 0.5 - 20 gmL-1. 

Published
Dec 1, 2008
How to Cite
, horvertech; SABER, A. L.. Determination of Pioglitazone Hydrochloride in Tablets by High-Performance Liquid Chromatography. Pakistan Journal of Analytical & Environmental Chemistry, [S.l.], v. 9, n. 2, p. 4, dec. 2008. ISSN 2221-5255. Available at: <http://pjaec.pk/index.php/pjaec/article/view/181>. Date accessed: 23 nov. 2017.