Synthesis, Spectral Characterization and Antioxidant Activity of Tin(II)-Morin Complex

  • Qadeer K.Panhwar Dr. M. A. Kazi Institute of Chemistry, University of Sindh, Jamshoro, Pakistan & National Center of Excellence in Analytical Chemistry, University of Sindh, Jamshoro 76080, Pakistan
  • Shahabuddin Memon National Center of Excellence in Analytical Chemistry, University of Sindh, Jamshoro 76080, Pakistan

Abstract

The study focuses on the interaction between morin and Tin(II) and the resulting complex was characterized through various analytical techniques by comparing it with morin. The complexation was confirmed at first by UV-Vis study, which shows that addition of Tin(II) to morin may produce bathochromic shifts indicative of complex formation. IR spectral studies indicated that carbonyl has involved in coordination with Tin(II). Moreover, 1H-NMR studies validated that in conjunction with carbonyl, 3-OH of morin is more appropriate to be involved in complexation by replacement of its proton. Scavenging activities of morin and its Tin(II) complex on DPPH• radical showed the inhibitory rates of 65% and 49%, respectively. In addition, the reducing capacity of morin was outstanding at 0.5 and 2.0 mg/ml concentrations relative to Tin(II) complex. Overall, the study potentially shows the strong impact in order to design the anticancer drugs jointly from its cytotoxic potential and antioxidant activities, thereby selectively targeting the cancerous cells in result increasing their therapeutic index as well as extra advantages over other anticancer drugs. 

Published
Dec 3, 2012
How to Cite
K.PANHWAR, Qadeer; MEMON, Shahabuddin. Synthesis, Spectral Characterization and Antioxidant Activity of Tin(II)-Morin Complex. Pakistan Journal of Analytical & Environmental Chemistry, [S.l.], v. 13, n. 2, p. 10, dec. 2012. ISSN 2221-5255. Available at: <http://pjaec.pk/index.php/pjaec/article/view/213>. Date accessed: 18 oct. 2017.