Application of Cloud Point Method for Spectrophotometric Determination of Salbutamol Sulphate and Methyldopa

  • Theia'a Najim Al-Sabha Mosul University

Abstract

A simple and efficient cloud point spectrophotometric method has been used for the determination of
salbutamol sulphate andmethyldopa both in pure and pharmaceutical preparations.The procedurewas based
on the ion association formation with eosin Y. The extraction of ion association, drown to Triton X-114
micelles,wasmeasured spectrophotometrically. The phase separationwas studied and optimized.Beer's law
was rectilinear over the concentration ranges of 0.1-20 and 0.3-10 μg/mLwithmolar absorptivity 4x104 and
5.7x104 L.mol-1 cm-1 and average recovery 98.21% and 101.27% for the above drugs, respectively. The
method was applied successfully for the determination of salbutamol sulphate and methyldopa in
pharmaceuticals.

Published
Jun 19, 2020
How to Cite
AL-SABHA, Theia'a Najim. Application of Cloud Point Method for Spectrophotometric Determination of Salbutamol Sulphate and Methyldopa. Pakistan Journal of Analytical & Environmental Chemistry, [S.l.], v. 21, n. 1, p. 10-18, june 2020. ISSN 2221-5255. Available at: <http://pjaec.pk/index.php/pjaec/article/view/496>. Date accessed: 30 sep. 2020. doi: http://dx.doi.org/10.21743/pjaec/2020.06.02.