The Impact of Hyperthyroidism on Selected Serum Proteins and Metal Ions in the Population of Lahore and Its Surrounding Areas

  • Aisha Munawar University of Engineering and Technology, Lahore
  • zahid Ali The University of Lahore
  • Farzana Muneeb Radio Immuno Assay lab, INMOL Hospital, Lahore, Punjab, Pakistan
  • Abu Baker Shahid Radio Immuno Assay lab, INMOL Hospital, Lahore, Punjab, Pakistan
  • Ahmed Akrem Botany Division, Institute of Pure and Applied Biology, Bahauddin Zakariya University, 60800 Multan, Pakistan
  • Syed Abid Ali H.E.J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences (ICCBS), University of Karachi, Pakistan

Abstract

Inorganic metal ions and the proteins play an essential role in living systems. Different hormones
and cellular messengers regulate the hemostasis of organisms. Calcium, magnesium, iron and zinc
are abundantly distributed in human bodies and play vital role in many biochemical processes.
Albumin and ferritin are also the most abundant proteins present in our bodies and carrying out
important physiological processes. A disease state or a medical condition can perturb the normal
levels of metal ions and proteins in living systems. In the present study, we have analyzed the
serum concentration of Ca, Mg, Fe, Zn, albumin and ferritin of hyperthyroid patients. This study
includes 184 collected samples (52 normal subjects and 132 hyperthyroid patients), with age
group ranging between 11 to 75 years. During sample collection, only those patients were
included for whom hyperthyroidism was initially diagnosed but not taking any medicines yet. The
hyperthyroid state was determined by the correlation of FT3, FT4 and TSH. Serum Fe, Ca and
albumin levels were determined by spectrophotometric method, while Zu and Mg by atomic
absorption spectroscopy (AAS) and ferritin by radioimmunology assay (RIA). Obtained results
demonstrated the significant differences in the studied parameters as compared to the normal
subjects.

Published
Dec 23, 2019
How to Cite
MUNAWAR, Aisha et al. The Impact of Hyperthyroidism on Selected Serum Proteins and Metal Ions in the Population of Lahore and Its Surrounding Areas. Pakistan Journal of Analytical & Environmental Chemistry, [S.l.], v. 20, n. 2, p. 151-160, dec. 2019. ISSN 2221-5255. Available at: <http://pjaec.pk/index.php/pjaec/article/view/497>. Date accessed: 15 july 2024. doi: http://dx.doi.org/10.21743/pjaec/2019.12.19.