Quantitative Analysis of Serum Lipid Profile in Gallstone Patients and Controls

  • Naseem Aslam Channa Institute of Biochemistry, University of Sindh, Jamshoro, Pakistan
  • Fatehuddin khand Department of Biochemistry, ISRA University, Hyderabad, Sindh, Pakistan
  • Allah Bux Ghanghro Institute of Biochemistry, University of Sindh, Jamshoro, Pakistan
  • Ali Mohammad Soomro Department of Pharmacology, Faculty of Pharmacy, University of Sindh, Jamshoro, Pakistan

Abstract

The present study was undertaken to explore the possible role of serum lipid profile in gallstone formation. For this serum lipid profile such as total, free and bound cholesterol, LDL cholesterol, HDL cholesterol, triacylglycerols and total lipids were determined in 109 gallstone patients and 100 controls (matched for age, sex and with negative personal or family history of gallstones) treated at Liaquat University Hpspital, Jamshoro, Pakistan. Comparison for serum lipid profile between different groups of gallstone patients and controls revealed no significant variation except for the triacylglycerols and total lipids, which were differed significantly between females of up to 45 and above 45 years age. Comparison for serum lipid profile between pure cholesterol and mixed composition gallstone formers showed no significant difference (p>0.05) between the two groups. The serum lipid profile significantly varied between gallstone patients and controls except bound cholesterol level. Comparison of total cholesterol, free cholesterol, LDL cholesterol, HDL cholesterol, triacylglycerols and total lipids between gallstone patients and controls revealed that there was a significant difference between gallstone patients and controls for (a) females with or without gallstones, (b) females of up to 45 years age and (c) females having more than 3 children. HDL cholesterol is significantly decreased in all the groups of gallstone patients as compared to controls, whereas, bound cholesterol remained non significant in all the groups of gallstone patients when compared with controls. In conclusion, elevated serum total cholesterol, free cholesterol, LDL cholesterol, triacylglycerols and decreased levels of HDL cholesterolseem to play major contributing role in the pathogenesis of gallstones in females of upto 45 years age with more than three children.

Published
Jun 1, 2010
How to Cite
CHANNA, Naseem Aslam et al. Quantitative Analysis of Serum Lipid Profile in Gallstone Patients and Controls. Pakistan Journal of Analytical & Environmental Chemistry, [S.l.], v. 11, n. 1, p. 7, june 2010. ISSN 2221-5255. Available at: <http://pjaec.pk/index.php/pjaec/article/view/71>. Date accessed: 15 dec. 2017.