Determination of Lisinopril in Pure and Tablet form by Using 2-Hydroxynaphthaldehyde as Derivatizing Reagent

Lisinopril; Spectrophotometry; 2HNA, derivatization

  • zahid ali zounr Dr. M.A. Kazi Institute of Chemistry, University of Sindh, Jamshoro, Pakistan, 76080

Abstract

An easy, sensitive and accurate spectrophotometric method has been developed for the
determination of Lisinopril (LNP) in pure and tablet formulations based on derivatization reaction
with 2-hydroxynaphthaldehyde (2HNA). The derivatization reaction was carried out in methanol
solvent at pH-5.5 at 95±2C for 15 min. The linear calibration curve was obtained that obeyed the
Beer’s law within the concentration range 5-50 μgmL-1 of LNP at 433 nm with a coefficient of
determination R²=0.996. The recovery was in the range from 98.25-101.82 with molar absorptivity
of drug 9×103 mole-1cm-1. The method was accurate and precise (intra-day variation 0.05-0.97%
and inter-day 0.07-1.6%), with limit of detection (LOD) and limit of quantification (LOQ) 0.264
μgmL-1 and 0.8 μgmL-1, respectively. No interferences from the excipients were detected. The
method was applied for the rapid analysis of LNP in pharmaceutical products.

Published
Jun 23, 2021
How to Cite
ZOUNR, zahid ali. Determination of Lisinopril in Pure and Tablet form by Using 2-Hydroxynaphthaldehyde as Derivatizing Reagent. Pakistan Journal of Analytical & Environmental Chemistry, [S.l.], v. 22, n. 1, p. 115-126, june 2021. ISSN 2221-5255. Available at: <http://pjaec.pk/index.php/pjaec/article/view/724>. Date accessed: 29 july 2021. doi: http://dx.doi.org/10.21743/pjaec/2021.06.12.