A Simple Spectrophotometric Determination of Diclofenac Sodium in Commercial Dosage Forms using 2,3-Dichloro-5, 6-Dicyano-1,4-Benzoquinone (DDQ)

  • TARIQ MAHMOOD ANSARI Department of Chemistry, Bahauddin Zakariya University Multan, 60800, Pakistan
  • ASAD RAZA Department of Chemistry, Bahauddin Zakariya University Multan, 60800, Pakistan
  • SHAHIDA BAGUM NIAZI Department of Chemistry, Bahauddin Zakariya University Multan, 60800, Pakistan
  • SYED IFTIKHAR HUSSAIN BUKHARI Department of Chemistry, University of Sargodha, Sargodha, Pakistan

Abstract

A rapid, simple and sensitive spectrophotometric method has been developed for the determination of diclofenac sodium in pure and tablet formulations. The method depends on the charge–transfer complexation between diclofenac sodium as n-electron donor with 2,3-Dichloro-5, 6-Dicyano-1,4-Benzoquinone (DDQ) in acetonitrile medium as π-acceptor to give a colored complex which absorbs maximally at 545 nm. Beer’s law has been obeyed in the concentration range of 13-275 µg ml-1 with molar absorptivity of   2.5 × 103 L mole-1 cm-1. The proposed method is precise, accurate and specific for routine quantitative analysis of  the drug in bulk and dosage forms. 

Published
Jun 1, 2005
How to Cite
ANSARI, TARIQ MAHMOOD et al. A Simple Spectrophotometric Determination of Diclofenac Sodium in Commercial Dosage Forms using 2,3-Dichloro-5, 6-Dicyano-1,4-Benzoquinone (DDQ). Pakistan Journal of Analytical & Environmental Chemistry, [S.l.], v. 6, n. 1, p. 5, june 2005. ISSN 2221-5255. Available at: <http://pjaec.pk/index.php/pjaec/article/view/85>. Date accessed: 22 sep. 2017.