A Simple Spectrophotometric Determination of Diclofenac Sodium in Commercial Dosage Forms using 2,3-Dichloro-5, 6-Dicyano-1,4-Benzoquinone (DDQ)
A rapid, simple and sensitive spectrophotometric method has been developed for the determination of diclofenac sodium in pure and tablet formulations. The method depends on the charge–transfer complexation between diclofenac sodium as n-electron donor with 2,3-Dichloro-5, 6-Dicyano-1,4-Benzoquinone (DDQ) in acetonitrile medium as π-acceptor to give a colored complex which absorbs maximally at 545 nm. Beer’s law has been obeyed in the concentration range of 13-275 µg ml-1 with molar absorptivity of 2.5 × 103 L mole-1 cm-1. The proposed method is precise, accurate and specific for routine quantitative analysis of the drug in bulk and dosage forms.
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