Application of Cloud Point Method for Spectrophotometric Determination of Salbutamol Sulphate and Methyldopa
Abstract
A simple and efficient cloud point spectrophotometric method has been used for the determination of
salbutamol sulphate andmethyldopa both in pure and pharmaceutical preparations.The procedurewas based
on the ion association formation with eosin Y. The extraction of ion association, drown to Triton X-114
micelles,wasmeasured spectrophotometrically. The phase separationwas studied and optimized.Beer's law
was rectilinear over the concentration ranges of 0.1-20 and 0.3-10 μg/mLwithmolar absorptivity 4x104 and
5.7x104 L.mol-1 cm-1 and average recovery 98.21% and 101.27% for the above drugs, respectively. The
method was applied successfully for the determination of salbutamol sulphate and methyldopa in
pharmaceuticals.
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
Submission of a manuscript to the Journal will be taken to imply that:
- The work is original and has not been previously published (except in the form of an abstract or a part of a published lecture, review or thesis).
- It is not being considered for publication elsewhere, and
- If accepted for publication, it will NOT be published commercially elsewhere in the same form, in any language, without the consent of Editor or Publisher.
