The Impact of Hyperthyroidism on Selected Serum Proteins and Metal Ions in the Population of Lahore and Its Surrounding Areas
Inorganic metal ions and the proteins play an essential role in living systems. Different hormones
and cellular messengers regulate the hemostasis of organisms. Calcium, magnesium, iron and zinc
are abundantly distributed in human bodies and play vital role in many biochemical processes.
Albumin and ferritin are also the most abundant proteins present in our bodies and carrying out
important physiological processes. A disease state or a medical condition can perturb the normal
levels of metal ions and proteins in living systems. In the present study, we have analyzed the
serum concentration of Ca, Mg, Fe, Zn, albumin and ferritin of hyperthyroid patients. This study
includes 184 collected samples (52 normal subjects and 132 hyperthyroid patients), with age
group ranging between 11 to 75 years. During sample collection, only those patients were
included for whom hyperthyroidism was initially diagnosed but not taking any medicines yet. The
hyperthyroid state was determined by the correlation of FT3, FT4 and TSH. Serum Fe, Ca and
albumin levels were determined by spectrophotometric method, while Zu and Mg by atomic
absorption spectroscopy (AAS) and ferritin by radioimmunology assay (RIA). Obtained results
demonstrated the significant differences in the studied parameters as compared to the normal
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