Evaluation of Antibacterial Activity of Zinc Oxide Nanoparticles and Acrylamide Composite Against Multidrug-Resistant Pathogenic Bacteria
Emerging antibiotic resistance in pathogenic bacteria is creating serious crises in therapeutic
options for treating infections worldwide. Thus, in the quest of alternative efficacious antibacterial
therapy, various previous studies have demonstrated that the coating material used for the
synthesis of Zinc oxide nanoparticles has tremendously improved the antibacterial activity of
nanoparticles. The aim of current study was to investigate the antibacterial activities of Zinc oxide
nanoparticles and acrylamide composite (ZnO-Am-NPs) against multidrug-resistant pathogenic
bacteria. Isolation and identification was performed by using standard conventional and
biochemical techniques. The antimicrobial activity of ZnO-Am-NPs was determined by using
modified agar well diffusion assay. The efficacy of ZnO-Am-NPs was compared with
commercially available standard antibiotics discs. The data showed that ZnO-Am-NPs possessed
strong antibacterial activity against multidrug-resistant pathogenic bacteria including Escherichia
coli, Pseudomonas aeruginosa, Klebsiella pneumoniae, and Staphylococcus aureus, suggesting
that coating of ZnO-NPs with acrylamide resulted in the broad spectrum antibacterial activity. The
antibacterial activity increased with the increasing concentration of ZnO-Am-NPs whereas the
minimum inhibitory concentration of ZnO-Am-NPs was recorded as 12.5μg/ml. The results of
present study indicated that the ZnO-Am-NPs may serve as promising antibacterial agents against
multidrug resistant and medically important bacteria.
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