Blood Chemistry (Hematology) of Transfusion Dependent Beta Thalassemia Patients at Hyderabad and Adjoining Areas

Abstract

Present study was carried out to analyze quantitatively the blood parameters of Transfusion Dependent Thalassemia (TDT) patients. A total number of seventy one (n=71) TDT patients aged 04 to 26 years were selected from Fatimid foundation center, Hyderabad from June 2015 to May 2016 and eighty four (n=84) control subjects (age, gender and locality matched persons with negative personal and family history of thalassemia) were included in this study. Blood sample of 5mL was collected from each participant to analyze white blood cells (WBC); total leukocytes counts (TLC); red blood cells (RBC); mean corpuscular value (MCV); mean corpuscular hemoglobin (MCH); mean corpuscular hemoglobin concentration (MCHC); hemoglobin (HB) and hematocrit (HCT). All the patients and control subjects were interviewed through a standard questionnaire specially developed to study their life style and dietary habits. The collected data from TDT patients and control subjects was statistically analyzed by using p<0.05 as statistically significant variation between two groups. Results revealed significantly decreased  evels of HCT, MCV, MCH and platelets in TDT patients as compared to control subjects. All TDT patients were frequently undergoing blood transfusion within the age groups.