Determination of Tapentadol Hydrochloride in Tablets by Three New Validated Spectrophotometric Methods

  • Deepti Jain School of Pharmaceutical Sciences, Rajiv Gandhi Technological University, Bhopal – 462 033, Madhya Pradesh, India
  • Pawan Kumar Basniwal School of Pharmaceutical Sciences, Rajiv Gandhi Technological University, Bhopal – 462 033, Madhya Pradesh, India and LBS College of Pharmacy, Jaipur – 302 004, Rajasthan, India

Abstract

Three UV spectrophotometric methods viz. linear regression equation (LRE), standard absorptivity (SA) and first order derivative (FOD) method were developed and validated according to ICH guideline. The methods were linear in the range of 10-50 µg/mL and validated methods were successfully applied for determination of tapentadol hydrochloride content in tablet dosage forms in the range of 100.42-100.64%, 100.31-100.54% and 100.10-100.59%, respectively. The standard deviation for all the methods was found to be less than one unit (0.450.83). The validated spectrophotometric methods may be successfully applied for assay, dissolution studies, bio-equivalence studies as well as routine analysis in pharmaceutical industries

Published
Jun 3, 2013
How to Cite
JAIN, Deepti; BASNIWAL, Pawan Kumar. Determination of Tapentadol Hydrochloride in Tablets by Three New Validated Spectrophotometric Methods. Pakistan Journal of Analytical & Environmental Chemistry, [S.l.], v. 14, n. 2, p. 6, june 2013. ISSN 2221-5255. Available at: <http://pjaec.pk/index.php/pjaec/article/view/223>. Date accessed: 15 dec. 2017.