Cathodic Stripping Voltammetric Determination of Cefadroxil in Pharmaceutical Preparations and in Blood Serum
An analytical method has been developed using hanging mercury drop electrode (HMDE) for the quantitative determination of antibacterial drug cefadroxil (CFL) from pharmaceutical preparations and blood serum. Cathodic adsorptive stripping voltammetry was carried out in hydrochloric acid (0.1M): methanol (80: 20 v/v) and potassium chloride (0.1M) as supporting electrolyte. The reduction wave was obtained within -700 to -800 mV. Linear calibration curve was within 1-50g/mL with detection limit of 0.1g/mL of cefadroxil. Relative standard deviation for inter and intra day analysis of CFL was within 1-2%. The number of additives present in pharmaceutical preparations did not interfere the determination of cefadroxil. The analysis of pharmaceutical preparations and blood serum after chemotherapy with cefadroxil indicated relative standard deviation (RSD) within 0.8-1.2% and 2.6-3.8% respectively. The satisfactory results were obtained for quality control of cefadroxil in pharmaceutical preparations and in blood serum.
Submission of a manuscript to the Journal will be taken to imply that:
- The work is original and has not been previously published (except in the form of an abstract or a part of a published lecture, review or thesis).
- It is not being considered for publication elsewhere, and
- If accepted for publication, it will NOT be published commercially elsewhere in the same form, in any language, without the consent of Editor or Publisher.