Cathodic Stripping Voltammetric Determination of Cefadroxil in Pharmaceutical Preparations and in Blood Serum

  • AMBER R. SOLANGI National Center of Excellence in Analytical Chemistry, University of Sindh, Jamshoro, Pakistan
  • ARFANA MALLAH M.A. Kazi Institute of Chemistry, University of Sindh, Jamshoro, Pakistan
  • M. Y. KHUHAWAR M.A. Kazi Institute of Chemistry, University of Sindh, Jamshoro, Pakistan
  • M. I. BHANGER National Center of Excellence in Analytical Chemistry, University of Sindh, Jamshoro, Pakistan

Abstract

An analytical method has been developed using hanging mercury drop electrode (HMDE) for the quantitative determination of antibacterial drug cefadroxil (CFL) from pharmaceutical preparations and blood serum. Cathodic adsorptive stripping voltammetry was carried out in hydrochloric acid (0.1M): methanol (80: 20 v/v) and potassium chloride (0.1M) as supporting electrolyte. The reduction wave was obtained within -700 to -800 mV. Linear calibration curve was within 1-50g/mL with detection limit of 0.1g/mL of cefadroxil. Relative standard deviation for inter and intra day analysis of CFL was within 1-2%. The number of additives present in pharmaceutical preparations did not interfere the determination of cefadroxil. The analysis of pharmaceutical preparations and blood serum after chemotherapy with cefadroxil indicated relative standard deviation (RSD) within 0.8-1.2% and 2.6-3.8% respectively. The satisfactory results were obtained for quality control of cefadroxil in pharmaceutical preparations and in blood serum.

Published
Jun 1, 2006
How to Cite
SOLANGI, AMBER R. et al. Cathodic Stripping Voltammetric Determination of Cefadroxil in Pharmaceutical Preparations and in Blood Serum. Pakistan Journal of Analytical & Environmental Chemistry, [S.l.], v. 7, n. 2, p. 5, june 2006. ISSN 2221-5255. Available at: <http://pjaec.pk/index.php/pjaec/article/view/27>. Date accessed: 21 apr. 2018.