Simpler and Faster Spectrophotometric Determination of Diclofenac Sodium in Tablets, Serum and Urine Samples

  • Abdul Rauf khaaskheli National Center of Excellence in Analytical Chemistry, University of Sindh 76080, Jamshoro 76080, Pakistan
  • Siraj uddin Pakistan Council of Scientific and Industrial Research Laboratories, Karachi 75280, Pakistan
  • Kamran Abro National Center of Excellence in Analytical Chemistry, University of Sindh 76080, Jamshoro 76080, Pakistan , Pakistan Council of Scientific and Industrial Research Laboratories, Karachi 75280, Pakistan
  • S. T. H. Sherazi National Center of Excellence in Analytical Chemistry, University of Sindh 76080, Jamshoro 76080, Pakistan
  • H. I. Afridi National Center of Excellence in Analytical Chemistry, University of Sindh 76080, Jamshoro 76080, Pakistan
  • S. A. Mahesar National Center of Excellence in Analytical Chemistry, University of Sindh 76080, Jamshoro 76080, Pakistan
  • Munawar Saeed National Center of Excellence in Analytical Chemistry, University of Sindh 76080, Jamshoro 76080, Pakistan

Abstract

This work describes a simple, sensitive, rapid and economical analytical procedure for direct spectrophotometric evaluation of diclofenac sodium (DS) using aqueous medium without using a chemical reagent. Parameters like time, temperature, acidic and basic conditions and interference by analgesic drugs were studied for a 5µg ml-1 solution of DS at 276 nm. Under optimized parameters, a linear working range of 0.1–30 g ml-1 with regression coefficient of 0.9998 and lower detection limit of 0.01 g ml-1 was obtained. The method was applied for DS contents in tablets, serum and urine samples.

Published
Dec 1, 2009
How to Cite
KHAASKHELI, Abdul Rauf et al. Simpler and Faster Spectrophotometric Determination of Diclofenac Sodium in Tablets, Serum and Urine Samples. Pakistan Journal of Analytical & Environmental Chemistry, [S.l.], v. 10, n. 1 & 2, p. 6, dec. 2009. ISSN 2221-5255. Available at: <http://pjaec.pk/index.php/pjaec/article/view/36>. Date accessed: 19 dec. 2018.