The Impact of Hyperthyroidism on Selected Serum Proteinsand Metal Ions in the Population of Lahore and its Surrounding Areas

Aisha Munawar; Zahid Ali; Farzana Muneib; Abu Baker Shahid; Ahmed Akrem; Syed Abid Ali

doi:10.21743/pjaec/2019.12.19

Authors

Aisha Munawar Department of Chemistry, University of Engineering and Technology, Lahore, Punjab, Pakistan. 2Department of Chemistry, The University of Lahore, Lahore, Pakistan Author
Zahid Ali Department of Chemistry, University of Engineering and Technology, Lahore, Punjab, Pakistan. 2Department of Chemistry, The University of Lahore, Lahore, Pakistan Author
Farzana Muneib Radio Immuno Assay lab, INMOL Hospital, Lahore, Punjab, Pakistan Author
Abu Baker Shahid Radio Immuno Assay lab, INMOL Hospital, Lahore, Punjab, Pakistan Author
Ahmed Akrem Botany Division, Institute of Pure and Applied Biology, Bahauddin Zakariya University, Multan, Pakistan Author
Syed Abid Ali H.E.J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences (ICCBS), University of Karachi, Karachi, Pakistan Author

DOI:

https://doi.org/10.21743/pjaec/2019.12.19

Keywords:

Ferritin, Albumin, Hyperthyroidism, Zinc, Iron, Calcium, Magnesium, TSH

Abstract

Inorganic metal ions and the proteins play an essential role in living systems. Different hormones and cellular messengers regulate the hemostasis of organisms. Calcium, magnesium, iron and zinc
are abundantly distributed in human bodies and play vital role in many biochemical processes. Albumin and ferritin are also the most abundant proteins present in our bodies and carrying out important physiological processes. A disease state or a medical condition can perturb the normal
levels of metal ions and proteins in living systems. In the present study, we have analyzed the serum concentration of Ca, Mg, Fe, Zn, albumin and ferritin of hyperthyroid patients. This study includes 184 collected samples (52 normal subjects and 132 hyperthyroid patients), with age group ranging between 11 to 75 years. During sample collection, only those patients were included for whom hyperthyroidism was initially diagnosed but not taking any medicines yet. The hyperthyroid state was determined by the correlation of FT₃, FT₄ and TSH. Serum Fe, Ca and albumin levels were determined by spectrophotometric method, while Zu and Mg by atomic absorption spectroscopy (AAS) and ferritin by radioimmunology assay (RIA). Obtained results demonstrated the significant differences in the studied parameters as compared to the normal subjects.