Evaluation of Bioelement Levels in Rat Tissues in Organophosphate Insecticide (Malathion) Toxicity:Effects of Caffeic Acid Phenethyl Ester (CAPE)

Abstract

In this study, it is aimed to investigate the effects of caffeic acid phenethyl ester (CAPE) on bioelement levels of plasma, brain, kidney and liver tissues against malathion toxication in rats. The rats in Control group were fed with standard feed and water. Carrier chemicals given to rats were called Sham group. 0.8 gkg^-1 malathion injected animals named MAL group. 10 μMkg-1 CAPE injection rats were in CAPE group. To the CAPE+MAL group, first 10 μMkg^-1 CAPE was administered, after one hour, 0.8 gkg^-1 malathion was injected. To the MAL+CAPE group, 0.8 gkg^-1 malathion was injected, after an hour, 10 μMkg^-1 CAPE was administered. Bioelement concentrations in blood and tissue samples were measured using inductively coupled plasmaoptical emission spectroscopy (ICP-OES). From the obtained data, Cu, Zn, Se, Pb, Fe, Mn level changes were remarkable. These elements are important because of their involvement in the antioxidant defense system and metallothioenin structure. The obtained bioelement concentrations show that malathion is an important factor for oxidative stress, and CAPE may an effective agent against lipid peroxidation induced oxidative damage in tissues.